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For example, most medications for erectile dysfunction work by limiting the effects of the PDE5 enzyme, which regulates the flow of blood to your penis. At 24 hours the plasma levels of sildenafil were still approximately 200 nanogram mL, compared to approximately 5 nanogram mL when sildenafil was dosed alone. So it seems like you can t miss it many people like to make a scheduled appointment. While the vast majority of patients with ED will have organic disease, some may have a primary psychological issue particularly younger men.

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