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You should always contact your doctor or other qualified healthcare professional before starting, changing, or stopping any kind of health treatment. It is important to remember that sildenafil is a prescription drug and should never be used if not prescribed to you personally by a doctor. Istradefylline 40 mg day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Cimetidine , a non specific CYP3A4 inhibitor, caused a 56 increase in plasma sildenafil concentrations when coadministered with sildenafil to healthy volunteers.

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