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The patient should also be warned that people who have undergone NAION are at high risk of re developing optic neuropathy. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Lopinavirlopinavir will increase the level or effect of sildenafil by affecting hepatic intestinal enzyme CYP3A4 metabolism. A doctor will review your consultation and message you with a suggestion within 1 2 working days.

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