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Physicians should inform patients not to take VIAGRA with other PDE5 inhibitors including REVATIO or other pulmonary arterial hypertension treatments containing sildenafil. This might be in part because the MnSOD downregulation in AD hippocampal neurons contributes to tau hyperphosphorylation , and low dose sildenafil appears to upregulate MnSOD via PGC1 activation 69 72. Grapefruit juice may increase sertraline levels in the blood by inhibiting the breakdown of sertraline.

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