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Expert Reveals Dangers Of Penis Enlargement Cream Penis enlargement creams are not regulated, so it is impossible to know what ingredients they contain or in what amounts. Not all supplements are unsafe, but uncomfortable and even permanent side effects are possible. Some side effects are mild, including 1. Irritation of the skin 2. rashes and bumps 3. blisters filled with fluid 4. itchiness or burning at the site of application These side effects can get worse or progress into more serious symptoms, including: 1. hives 2. pus or discharge from blisters or rash 3. infections in broken skin from scratching, which can also make you more susceptible to sexually transmitted infections (STIs). These symptoms, if left untreated, can result in permanent scarring or damage to your penis. Anaphylaxis, a potentially fatal allergic reaction, is also a possibility. If you have difficulty breathing, severe pain, or severe swelling, you should seek emergency medical attention. If your partner is allergic to any of the cream's ingredients, they may also experience these side effects. Some oils also break down the materials in latex condoms, which aren't usually made to be resistant to certain types of oil lubrication. This can increase your risk of STI transmission or unwanted pregnancy. The side effects can become even more painful or life-threatening if the cream gets directly into the vagi.