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However, sildenafil tablets may be taken anywhere from 30 minutes to 4 hours before sexual activity. The main measure of effectiveness was based on the ability of the men to get and maintain an erection. In nonpregnant rat the AUC at this dose was about 20 times human AUC. Participants with ED were given a 50mg starting dose in a research to see how well they would respond to having their sildenafil dose increase to 100mg.

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