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As one of the most popular nutritional plans available, the Keto diet continues to be studied for not only its effectiveness but the role it plays in treating a variety of medical disorders. Ketones can increase the of ATP hydrolysis and provide a source of cytoplasmic acetyl CoA that can blunt the lowering of acetyl choline characteristic of Alzheimer s brains. A search on cancer metabolism brings up 369,000 references, with 28,000 in 2013 alone. Hepatic mRNA expression of peroxisome proliferator activated receptor coactivator 1 PGC 1 , which is known to be induced by FGF21 , was also significantly increased Fig 3A.

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